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Hodgkin's disease, mixed cellularity type
Clinical features:
1) Usually adults, male > female.
2) Stage may be more advanced with lymph nodes, spleen, liver & bone marrow involvement.
3) Moderately aggressive course, often curable.
Pathology:
1) classic Reed-Sternberg and some lacunar cells seen.
2) lymphocytes, histiocytes, plasma cells, eosinophils & neutrophils present.
Immunophenotype: tumor cells
- CD15 +/-
- CD30 +
- CD45 -
- B-cell & T-cell antigens usually -
- EMA -
Genetics:
- Ig & TCR genes usually germline
- EBV +, 60-70%
Interactions
disease interactions
General
Hodgkin's disease (Hodgkin's lymphoma)
References
- Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML,
Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al.
A revised European-American classification of lymphoid
neoplasms: a proposal from the International Lymphoma Study
Group.
Blood. 1994 Sep 1;84(5):1361-92. Review.
PMID: 8068936